Pierce landed awkwardly after making a second-quarter layup. He crumpled to the floor, right leg pinned beneath him, writhing in pain.
Late Monday night, the Clippers said Pierce suffered a sprained right ankle as well as a bruised right knee. He is expected to miss about a week.
Pierce is averaging a career-low 17-plus minutes per game. That number might even drop more once forward Blake Griffin returns Sunday after being out the past three months.